GABAA Receptor Activity Suppresses the Transition from Inter-ictal to Ictal Epileptiform Discharges in Juvenile Mouse Hippocampus
نویسندگان
چکیده
منابع مشابه
Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations.
The cellular and network mechanisms of the transition of brief interictal discharges to prolonged seizures are a crucial issue in epilepsy. Here we used hippocampal slices exposed to ACSF containing 0 Mg(2+) to explore mechanisms for the transition to prolonged (3-42 sec) seizure-like ("ictal") discharges. Epileptiform activity, evoked by Shaffer collateral stimulation, triggered prolonged burs...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2018
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-018-0273-z